Antihemorrhagic properties of therapeutic botulinum toxin in experimental mice

Abstract

Botulinum toxin (BoNT) is a potent neurotherapeutic agent that blocks the aberrant release of the neurotransmitter acetylcholine containing vesicles at the neuromuscular junction. While excessive levels of acetylcholine have been linked to inhibition of platelet activities and abnormal bleeding disorders, BoNT treatment can be proposed to regulate the blood coagulation events upon haemorrhagic episodes. Thus, this study examined effect of BoNT treatment on the regulation of biochemical parameters of blood coagulation in experimental aging mice.